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81.
We consider the problem of locating facilities and allocating servers on a congested network (LASCN). Demands for service that originate from the nodes are assumed to be Poisson distributed and the servers provide a service time that is exponentially distributed. The objective is to minimize the total cost of the system which includes a fixed installation cost, a variable server cost, a cost associated with travel time and a cost associated with the waiting time in the facility for all the customers. The problem is formulated using non-linear programming and subsequently analyzed. Results for exact and approximate solution approaches are reported. We also show that we can modify the approaches to solve the LASCN with constraints limiting both the travel time to the servers and the waiting time of customers.  相似文献   
82.
We generalise the notion of a bubble beyond the financial domain, by showing how a single social mechanism, based on an information feedback-loop, explains both financial bubbles and other seemingly disparate social phenomena, such as the recognition of academic articles, website popularity, and the spread of rumours.

We discuss examples of phenomena explained by this bubble mechanism, as well as other phenomena that exhibit certain bubble characteristics, yet are not bubbles according to our model. Finally, we present mathematical mechanisms for two phenomena that conform with our model, and show by computer simulation how they exhibit bubble behaviour.  相似文献   
83.
    
An output-sensitive visibility algorithm is one whose runtime is proportional to the number of visible graphic primitives in a scene model—not to the total number of primitives, which can be much greater. The known practical output-sensitive visibility algorithms are suitable only for static scenes, because they include a heavy preprocessing stage that constructs a spatial data structure which relies on the model objects’ positions. Any changes to the scene geometry might cause significant modifications to this data structure. We show how these algorithms may be adapted to dynamic scenes. Two main ideas are used: first, update the spatial data structure to reflect the dynamic objects’ current positions; make this update efficient by restricting it to a small part of the data structure. Second, use temporal bounding volumes (TBVs) to avoid having to consider every dynamic object in each frame. The combination of these techniques yields efficient, output-sensitive visibility algorithms for scenes with multiple dynamic objects. The performance of our methods is shown to be significantly better than previous output-sensitive algorithms, intended for static scenes. TBVs can be adapted to applications where no prior knowledge of the objects’ trajectories is available, such as virtual reality (VR), simulations etc. Furthermore, they save updates of the scene model itself; notjust of the auxiliary data structure used by the visibility algorithm. They can therefore be used to greatly reduce the communications overhead in client-server VR systems, as well as in general distributed virtual environments.  相似文献   
84.
85.
The dynamic out-of-plane response of unreinforced masonry walls is investigated. The study combines analytical, numerical, and experimental methodologies. The paper focuses on structural schemes that involve supporting at the base and the top and yield a unidirectional (one-way) flexural action. First, the modeling concepts for the nonlinear dynamic analysis are discussed and used as a basis for a finite element formulation. The element is based on a first-order shear deformation theory with large displacements, moderate rotations, small strains, material nonlinearity, and a Rayleigh type of viscoelastic damping. The nonlinearities due to cracking and the inelastic response under cyclic compression are introduced through the constitutive model for the mortar. The experimental part includes shake-table testing under different levels of out-of-plane excitation and compressive loading. The experimental results and the numerical model quantify a range of physical phenomena, including the dynamic arching and rocking effects, the coupling of the axial (in the height direction) and the out-of-plane responses, the role of axial loading, and the vulnerability of the masonry construction to dynamic loads. The comparison between the numerical results and the experimental results examines the capabilities of the model and gains insight into the nonlinear dynamics of the masonry wall.  相似文献   
86.
87.
    
The cytoplasmic retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) initiate interferon (IFN) production and antiviral gene expression in response to RNA virus infection. Consequently, RLR signalling is tightly regulated by both host and viral factors. Tripartite motif protein 25 (TRIM25) is an E3 ligase that ubiquitinates multiple substrates within the RLR signalling cascade, playing both ubiquitination-dependent and -independent roles in RIG-I-mediated IFN induction. However, additional regulatory roles are emerging. Here, we show a novel interaction between TRIM25 and another protein in the RLR pathway that is essential for type I IFN induction, DEAD-box helicase 3X (DDX3X). In vitro assays and knockdown studies reveal that TRIM25 ubiquitinates DDX3X at lysine 55 (K55) and that TRIM25 and DDX3X cooperatively enhance IFNB1 induction following RIG-I activation, but the latter is independent of TRIM25’s catalytic activity. Furthermore, we found that the influenza A virus non-structural protein 1 (NS1) disrupts the TRIM25:DDX3X interaction, abrogating both TRIM25-mediated ubiquitination of DDX3X and cooperative activation of the IFNB1 promoter. Thus, our results reveal a new interplay between two RLR-host proteins that cooperatively enhance IFN-β production. We also uncover a new and further mechanism by which influenza A virus NS1 suppresses host antiviral defence.  相似文献   
88.
89.
Stainless steel AISI 304 surfaces were studied after a mild anodic polarization for oxide growth in the presence and absence of two derivatives of vitamin B2 (riboflavin and flavin mononucleotide) that can be secreted by metal-reducing bacteria and act as a chelating agent for iron species. The alterations in oxide chemistry were studied by means of surface-sensitive techniques such as X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry analysis. The complementary electrochemical characterization revealed a preferential growth of an oxide/hydroxide iron-rich film that is responsible for an altered pit initiation and nucleation behavior. These findings suggest that as the corrosion behavior is determined by the interplay of the chemical and electronic properties, only a mild anodic polarization in the presence of redox-active molecules is able to alter the chemical and electronic structure of the passive film formed on stainless steel AISI 304. This helps to achieve a profound understanding of the mechanisms of microbially influenced corrosion (MIC) and especially the possible effects of the redox-active biomolecules, as they may play an important role in the corrosion susceptibility of stainless steel surfaces.  相似文献   
90.
    
We present a simple and concise discretization of the covariant derivative vector Dirichlet energy for triangle meshes in 3D using Crouzeix-Raviart finite elements. The discretization is based on linear discontinuous Galerkin elements, and is simple to implement, without compromising on quality: there are two degrees of freedom for each mesh edge, and the sparse Dirichlet energy matrix can be constructed in a single pass over all triangles using a short formula that only depends on the edge lengths, reminiscent of the scalar cotangent Laplacian. Our vector Dirichlet energy discretization can be used in a variety of applications, such as the calculation of Killing fields, parallel transport of vectors, and smooth vector field design. Experiments suggest convergence and suitability for applications similar to other discretizations of the vector Dirichlet energy.  相似文献   
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